South Carolina Sen. Tim Scott, who leads the Senate GOP campaign arm, gave an animated speech, criticizing a slate of Democratic candidates before concluding that the only way to keep "dangerous, radical, weird" out of the Senate is a "united Republican Party."

"Standing with our President Donald J. Trump," he shouted, raising both hands in the air. "Stand for the President Donald J. Trump. This is a battle for the heart of our nation. I said the heart of our nation."

Scott pulled open his jacket and pounded his chest as he shouted, "The Democrats' extreme candidates won't rip that heart out of our chests. They hate our culture. They hate what it means to be American. Hear me Dallas? Not on our watch. We won't back down. We will not grow weary. Are you with me?"

Scott went on to criticize Texas Democratic Senate candidate James Talarico for believing that God is non-binary, comments that Talarico has walked back, and took a number of stabs at Michigan Democratic Senate candidate Abdul El-Sayed, saying that he "panders with terrorists."

-ABC News' Allison Pecorin

Texas Attorney General Ken Paxton, running in one of the most-watched Senate races this cycle, praised Trump and targeted his opponent, Democrat James Talarico.

Paxton attacked Talarico for his past comments, including saying that God is non-binary and called him the most "radical Democrat" in the history of Texas.

"He calls himself a Christian who hates Christianity, said God is non-binary. I must have missed that verse in the Bible," Paxton said.

When asked about his comments in recent months, Talarico has said that he missed the mark.

Despite Paxton speaking in his home state, the crowd was not as enthusiastic for him as other candidates. The Talarico attacks got him big cheers, but the parts of his speech focused on policy and platform had the crowd quiet.

-ABC News' Hannah Demissie and Diana Paulsen

Democratic Sen. John Fetterman made a surprise appearance at the convention via video on Wednesday to introduce his fellow Pennsylvanian Sen. Dave McCormick and to distance himself from socialism in his party.

"Yes, I'm Sen. John Fetterman, Pennsylvania. Yes I'm a Democrat. Why am I here talking to you today? Because, well, I'm a common sense Democrat. I'm always going to reject the extremes and socialism and that anti-American way of life" Fetterman said in what appeared to be a pre-recorded message.

Fetterman's appearance at a GOP event of this nature is highly atypical, but he notably made no announcement of any intention to change his party affiliation. Instead, he used his brief video, which features him standing in front of a U.S. Steel mill, to tout his willingness to collaborate with Trump and McCormick to "defend the steel way of life right here in the Steel Valley."

-ABC News' Allison Pecorin

The Republican nominee for Senate in North Carolina and former RNC Chair Michael Whatley used his time on the convention stage to praise Republican tax cuts and slam "radical Democrats" for high costs.

"With the November election just 55 days away, let's talk about what Republicans have accomplished for working families, and what radical Democrats have stood against," Whatley said.

"Under President Trump's leadership, Republicans passed the 'Working Families Tax Cuts' and put thousands of dollars back into the hands of families and seniors. My opponent, Roy Cooper, opposed this bill," Whatley said, drawing boos from the crowd.

Whatley is locked in a competitive race against former North Carolina Gov. Roy Cooper as Democrats view the battleground Senate seat being vacated by retiring Sen. Thom Tillis as one of their best pickup opportunities this year.

-ABC News' Halle Troadec